Research Articles
Validating Predictive Models for Final Adult Height in Growth Hormone-Treated Children: A Research and Clinical Perspective
This article synthesizes current research on the validation of predictive models for final adult height in children undergoing growth hormone (GH) treatment.
Combating Waning Efficacy in Long-Term Growth Hormone Therapy: Mechanisms, Predictive Modeling, and Novel Formulations
This article synthesizes current research and future directions for managing the progressive decline in growth velocity observed during long-term growth hormone (GH) therapy.
Long-Term Somatic and Bone Health Outcomes of Puberty Suppression in Transgender Youth: A Scientific Review for Researchers and Drug Developers
This article synthesizes current evidence on the long-term effects of gonadotropin-releasing hormone analogues (GnRHa) on somatic growth and bone health in transgender adolescents.
Validating the Carolina Premenstrual Assessment Scoring System (C-PASS): A New Standard for PMDD Diagnosis in Research and Drug Development
This article provides a comprehensive analysis of the Carolina Premenstrual Assessment Scoring System (C-PASS), a standardized protocol for diagnosing DSM-5 Premenstrual Dysphoric Disorder (PMDD).
Parallelism Recovery Assay Validation in Hormone Measurement: Principles, Methods, and Best Practices for Robust Bioanalytical Data
This article provides a comprehensive guide to parallelism recovery assay validation, a critical process for ensuring the accuracy and reliability of hormone measurements in biological matrices.
Neuroendocrine Profiles Compared: Oral Contraceptives vs. Naturally Cycling Women in Biomedical Research
This article synthesizes current research on the distinct neuroendocrine profiles of oral contraceptive (OC) users and naturally cycling (NC) women, a critical consideration for drug development and clinical research.
Achieving Analytical Precision: Setting Variability Goals for Robust Hormone Assay Validation
This article provides a comprehensive framework for researchers, scientists, and drug development professionals on establishing analytical variability goals for hormone assay validation.
Multilevel Modeling with Random Effects for Longitudinal Data in Biomedical Research: From Foundational Concepts to Clinical Applications
This article provides a comprehensive guide to multilevel modeling (MLM) with random effects for the analysis of longitudinal data in biomedical and drug development research.
Beyond the Detection Limit: Advanced Strategies for Analyzing Undetectable Hormone Data
This article provides a comprehensive guide for researchers and drug development professionals on handling non-detectable hormone concentrations, a common challenge that can compromise data integrity and lead to biased conclusions.
Beyond the 28-Day Myth: A Scientific Analysis of Follicular and Luteal Phase Variance
This article synthesizes current research on follicular and luteal phase length variability, challenging the classical paradigm of a fixed 14-day luteal phase.