Research Articles
Beyond the Calendar: Critical Limitations of Calendar Counting Methods in Clinical and Biomedical Research
This article critically examines the use of calendar-based counting methods for determining menstrual cycle phases in research settings.
Serum vs. Saliva Hormone Testing: A Scientific Guide for Phase Verification in Clinical Research
This article provides a comprehensive, evidence-based analysis of serum and saliva hormone testing methodologies for researchers and drug development professionals engaged in clinical phase verification.
Beyond Counting Days: A Researcher's Guide to Valid Menstrual Cycle Phase Determination with Hormone Assays
Accurately determining menstrual cycle phase is critical for biomedical research, yet methodological inconsistencies and a reliance on estimation undermine data validity.
Defining the Phases: Establishing a Scientific Consensus for Menstrual Cycle Nomenclature in Research and Drug Development
This article addresses the critical lack of standardized definitions and methodologies for characterizing menstrual cycle phases in biomedical research.
Estradiol and Progesterone: Master Regulators of Substrate Metabolism in Health and Disease
This review synthesizes current research on the intricate roles of estradiol and progesterone in regulating substrate metabolism.
Neuroendocrine Orchestration: How Ovarian Hormone Fluctuations Govern Neurotransmitter Regulation and Influence Mental Health & Addiction
This article synthesizes current evidence on the dynamic interplay between ovarian hormones (estradiol and progesterone) and central neurotransmitter systems.
Menstrual Cycle Phase and Injury Risk in Athletes: A Scientific Review of Hormonal Mechanisms, Evidence, and Research Methodologies
This article synthesizes current scientific evidence on the relationship between menstrual cycle phases and injury risk in female athletes, addressing a critical gap in sports medicine and pharmacology.
Progesterone at the Crossroads: Deciphering Its Dual Role in Neuroinflammation and Cognitive Processing Speed for Therapeutic Development
This review synthesizes current scientific evidence on the multifaceted role of progesterone in modulating neuroinflammatory pathways and reaction time, a key cognitive-motor metric.
Long-Term Metabolic Outcomes of Testosterone Formulations: A Comparative Analysis for Research and Development
This article synthesizes current evidence on the long-term metabolic effects of various testosterone replacement therapy (TRT) formulations, including injectables (cypionate, enanthate, undecanoate), transdermals, and pellets.
Timing Matters: A Comprehensive Analysis of Long-Term Neurocognitive Outcomes Following Early vs. Late Menopausal Hormone Therapy Initiation
This article synthesizes current evidence on the long-term neurocognitive impact of menopausal hormone therapy (mHT) timing.